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How Raspberry Ketones Work To Protect Your Liver

Sometimes, as a result of a high-fat diet, you tend to have excess fat in your blood that is not stored in your adipose tissue.

Sometimes this fat gets transported to other organs in your body, like your liver and your heart.

When fat accumulates in your liver, this condition is called non-alcoholic fatty liver disease.

Fatty liver disease used to be seen in alcoholics.

However, due to the increase in cases of metabolic syndrome, diabetes, and insulin resistance, fat accumulation in the liver has increased, with all age groups and populations.

Non-alcoholic fatty liver disease has been linked to decrease in liver function, and if not treated with medication, diet, or exercise, it may lead to the development of NASH.

NASH stands for non-alcoholic steatohepatitis, or an increase in cirrhosis of the liver without the presence of alcohol.
This condition can lead to destruction of your liver cells, and may even lead to death.

Raspberry ketones, the aromatic component of red raspberries, have been shown effective at preventing and protecting the liver against NASH.

One study published in the Journal of Medicinal Foods, shows that raspberry ketones may be effective at protecting your liver against NASH.

Let me explain…

Raspberry Ketones and NASH

NASH, which is characterized by inflammation and fat accumulation in the liver cells, is commonly found in the liver of alcoholics.

However, recent changes in overweight and obesity statuses, NASH is becoming a common occurrence in patients who are obese, suffer from metabolic syndrome, have insulin resistance, or are diabetic.

This destructive disease of the liver is starting to be seen in overweight or obese children, so stopping the process early, before cirrhosis sets in, is the best course of treatment.

Current research shows that raspberry ketones, a component in red raspberries, may provide protection to the liver, especially in the presence of a high-fat diet.

The authors of this study wanted to evaluate the protective nature of raspberry ketones on NASH by utilizing a high-fat NASH induced diet.

They separated 40 rats into one of five groups: control group (eight rats fed a normal diet for eight weeks), a model control group, a high-fat diet group, a raspberry ketone low-dose group, a raspberry ketone medium-dose group, and a raspberry high-dose group all of which were fed a high-fat diet for four weeks.

They assessed total cholesterol, triglycerides, HDL and LDL cholesterol, Leptin levels, free fatty acids levels, TNF-alpha levels, blood glucose, plasma insulin levels, and liver function parameters (ALT, AST, and ALP levels).

They showed that levels of triglycerides, total cholesterol, LDL cholesterol, ALT, AST, ALP, blood glucose levels, insulin levels, free fatty acids levels, leptin levels, TNF-alpha levels, CRP levels (inflammation levels) in the model control group was significantly increased. 

This resulted in a decrease in HDL cholesterol, insulin sensitivity index, PPAR-alpha levels, and other blood parameters.

However, when the researchers compared the three raspberry ketone groups to the model control group, they showed that all parameters improved.

From their work, they concluded that raspberry ketones may be an effective tool in treating NASH among rats.

They also believed that the effects were due to the dual effects of liver protection and fat reduction, which may have been caused by decreased liver inflammation, alleviation of fatty degeneration of liver cells, correction of dyslipidemia, reversal of leptin levels, and an improvement in antioxidant capacity.

Although this work still needs to be verified by other research and translated into human trials, it does provide promise for different treatment options for NASH and fatty liver disease.

Raspberry Ketones

Raspberry ketones have been shown to provide protection for your liver cells, especially as it relates to high-fat diet induced fat accumulation in your liver.

According to the results of this study, raspberry ketones could provide protection to your liver by decreasing inflammation, reducing fat accumulation, and improving antioxidant capacity.

Raspberry ketones, according to some studies, may stimulate fatty acid oxidation and increase fat burning in your body, which could lead to lower body fat levels and improvements in liver health when exposed to a high-fat diet.


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References:

Wang L, Meng X, Zhang F.  Raspberry ketone protects rats fed high-fat diets against nonalcoholic steatohepatitis.  J Med Food.  2012 May;15(5):495-503.