Eat Grapes For Weight Loss?

Adiponectin is a powerful protein that is produced and secreted by your fat cells.

And this hormone may play a vital role in your energy metabolism.

Adiponectin plays a similar role as Leptin, communicates with your brain, and may control energy levels and nutrient metabolism.

The role of adiponectin in your body is glucose and fatty acids metabolism.

Certain diseases, such as diabetes and obesity, may contribute to lower levels of adiponectin.

And this may increase your risk for developing chronic diseases like diabetes, certain cancers, and heart disease.

But it does not affect JUST obese individuals.

Let me explain…

Overweight and Your Health

Being even 10 pounds overweight may lead to significant changes to your cells.

And these metabolic changes may reduce your body’s ability to utilize powerful hormones responsible for weight loss, fat metabolism, and blood sugar control.

In fact, your cells may be RESISTANT to certain hormones.

If you are 10 or more pounds overweight, your production and secretion of 1 powerful protein, adiponectin, may be significantly lower.

And losing weight may increase your adiponectin levels.

Increased levels of adiponectin AND leptin may REVERSE insulin resistance in mice.

So how can you increase your levels of adiponectin?

I am glad you asked!

Resveratrol and Adiponectin

There are many factors responsible for increasing your adiponectin levels.

And all of them work to produce and secrete adiponectin from your fat cells.

But there may be a new PLAYER in the production of adiponectin.

DsbA-L is an important protein that may increase intracellular levels and the secretion of adiponectin.

Increased levels of DsbA-L may be an integral component in the formation of adiponectin and the secretion of adiponectin in adipocytes (FAT CELLS).

And decreased levels of DsbA-L may also decrease your levels of adiponectin.

In fact, overweight or obese individuals may have decreased expression of DsbA-L, which may account for the similar decrease in adiponectin.

And this may spell trouble for your WEIGHT LOSS.

But there is new evidence that resveratrol may play a crucial role in increasing the expression of DsbA-L in your blood.

And this may increase your adiponectin levels.

Resveratrol, a powerful polyphenol which is found in the skin of grapes and in red wine, may play a powerful role as an antioxidant and an anti-fungal component.

In humans, resveratrol may provide an anti-inflammatory and anti-cancer effect, better control of blood glucose, and other beneficial effects for your cardiovascular system.

Now resveratrol may potentially increase adiponectin levels.

Resveratrol may promote the multimerization, or the assembly of the components of certain cells, at cellular levels of adiponectin.

By suppressing the expression of DsbA-L, researchers noticed a similar decrease in adiponectin.

However, by suppressing the AMPK and FOXO1 pathways, they noticed a down regulation in the expression of DsbA-L, which also decreased adiponectin levels.

They noted that resveratrol increased the expression of DsbA-L and the production and secretion of adiponection.

And this may have been accomplished by an independent Sirt1 channel.

The researchers concluded that expression of DsbA-L plays a critical role in resveratrol’s ability to affect adiponectin levels, both on intracellular and circulating levels.

Your Diet Matters

Resveratrol, which is a naturally occurring polyphenol found in the skin of grapes, wine, and other berries, may possess antioxidant power.

It may provide anti-inflammatory and anti-cancer effects, lower blood sugar, and other potential benefits for your cardiovascular system and the rest of your body.

Now, resveratrol may increase the expression of a powerful protein, which may be produced and secreted from your fat cells.

By increasing the expression of DsbA-L, resveratrol may increase the production of adiponectin in your fat cells.

And this may increase glucose and fatty acid metabolism, which may aid in weight loss.

By increasing adiponectin levels, you may stimulate weight loss through fatty acid metabolism.

Increasing your intake of grapes and other berries that contain resveratrol may increase your body’s ability to burn fat, and may aid in weight loss.

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References:

Wang, Z.  Scherer, P.  DxbA-L is a versatile player in adiponectin secretion.  PNAS.  2008.  Vol. 105(47): pp. 18077-18078.

Wang, A.  Liu, M. Liu, X.  Don, LQ.  Glickman, R.  Slaga, T.  Zhou, Z.  Liu, F.  Up-regulation of Adiponectin by Resveratrol.  THE ESSENTIAL TOLES OF THE AkT/FOXO1  AND AMP-ACTIVATED PROTEIN KINASE SIGNALING PATHWAY AND DsbA-L.  The Journal Of Biological Chemistry.  2011.  Vol. 286: pp. 60-66.